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Egyptian Pediatric Association Gazette
Fig. 3 | Egyptian Pediatric Association Gazette

Fig. 3

From: Relationship of thymic area with clinical-epidemiological variables and values of T-lymphocyte subpopulations in peripheral blood of children with recurrent infections

Fig. 3

Cellular immunophenotypes by flow cytometry according to thymus development depending on its area in children with recurrent infections. The multiparametric analysis (relative and absolute frequencies) is based on the values of flow cytometry of cellular subpopulations, CD45+ CD3+, CD45+ CD3+ CD4+, CD45+ CD3+ CD8+ and of subpopulations of cells T CD4+ and T CD8+ naïve (CD45RA+ CD27+) and of memory cells (central memory cells, CM, CD45RA- CD27+; memory effector cells, EM, CD45RA- CD27−; terminally differentiated T effector cells, TEMRA, CD45RA+ CD27−). Each point represents an individual with a normal thymus area (N, gray, n = 25), slight thymic hypoplasia (HSL, blue, n = 19), and moderate and severe thymus hypoplasia (HM-S, red, n = 29). The analysis of distribution comparison between groups was made using the U Mann-Whitney test with a level of significance of p < 0.05. The p-values and their significance were *p < 0.05. No differences were found in the CD4/CD8 index on comparing the groups. Abbreviations: IQR interquartile range

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