Table 1 Indications for HSCT among the studied SCD children (n = 128)

Overt stroke

2 (1.6%)

Cerebrovascular disease

2 (1.6%)

Alloimmunization to red blood cells with a recognized indication for a chronic transfusion regimen

1 (0.8%)

Recurrent severe pain episodes despite hydroxyurea (≥ 3/year)

66 (51.6%)

Recurrent acute chest syndrome despite hydroxyurea

6 (4.7%)

Increased TCD velocity is neither responsive to hydroxyurea nor a chronic transfusion regimen

11 (8.6%)

Elevated pulmonary artery pressure or detection of a tricuspid valve regurgitant jet velocity ≥ 2.7 m/s by echocardiography

5 (3.9%)

Bone and joint affection

15 (11.7%)

Total number of patients with any HSCT indication^a

69 (53.9%)