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Table 3 Common drugs that patients with G6PD deficiency should avoid or use with caution [27, 28]

From: Diagnosis, management and prevention of Pediatric Acute Hemolytic Anemia: Egyptian adapted evidence-based clinical practice guidelines

Generic name

Risk level

Generic name

Risk level

Acetaminophen

Low

Moxifloxacin

High

Acetylsalicylic acid

Variablea

Naphthalene

High

Ascorbic acid (vitamin C)

High with high dose

Nitric oxide

High

Chloramphenicol

High

Nitrofurantoin

High

Ciprofloxacin

High

Nitroglycerin

High

Colchicine

Low

Phenazopyridine (Pyridium)

High

Dapsone

High

Primaquine

Highb

Diphenhydramine

Low

Probenecid

High

Glimepiride

High

Rasburicase

Highc

Glipizide

High

Sodium nitroprusside

High

Glyburide

Use with caution

Streptomycin

Low

Hydroxychloroquine

High

Sulfacetamide

High

Isoniazid

Low

Sulfamethoxazole

Highd

Levofloxacin

High

Trimethoprim

Lowd

Methylene blue

High

Vitamin K

Low to highe

  1. aRisk level low to none, use with caution
  2. bReduce dose with medical therapy if required
  3. cPrescribing modification required
  4. dAlso, when in combination with the other drug
  5. eHigh with vitamin K3 (menadione), low with vitamin K1 (phytomenadione)