Table 1 Health questions used to develop this adapted clinical practice guideline

Diagnosis

History and clinical examination: (see Figs. 2 and 3)

Laboratory diagnosis:

1. What is the initial laboratory panel for infants, children, and adolescents presenting with AHA?

2. What is the best timing and test to diagnose G6PD deficiency in infants, children, and adolescents presenting with AHA?

3. What are the indications of G6PD testing?

4. What is the best test to diagnose AIHA in infants, children, and adolescents presenting with AHA?

5. What are the additional immunological tests before starting treatment in patients with AIHA?

6. What is the initial laboratory panel for patients with suspected post diarrheal hemolytic uremic syndrome?

Management

Emergency management:

1. What is the emergency treatment for infants, children, and adolescents presenting with AHA?

2. When are packed red cells indicated?

Sub-question: are volume/precautions needed?

Medical pharmacological treatment:

3. What is the medical treatment in infants, children, and adolescents with AIHA?

What are the criteria of adequate/good response to treatment in infants, children, and adolescents with AIHA?

Monitoring and follow-up

4. For follow-up after discharge, what are the laboratory tests needed in patients with G6PD and AIHA?

Prevention

1. What are the drugs to be avoided and the dietary modifications required to prevent the occurrence of AHA in patients with G6PD deficiency?

2. For prevention of HUS, when is empiric antibacterial treatment indicated for children with bloody diarrhea?