Skip to main content

Table 3 Demographic, clinical, and baseline laboratory data of survivors and non-survivors

From: ADAMTS13 in pediatric sepsis: a prognostic biomarker with potential therapeutic implications

Variable

Survivors (n = 46)

Non-survivors (n = 24)

p-value

General characteristics

Age, month

12 (4 – 48)

18 (6.5 – 102)

0.19

Male sex

20 (44.4%)

11 (44%)

0.97

Weight, Kg

8.6 (5.5 – 12.8)

8 (6.3 – 21)

0.32

Category

 Sepsis

35 (76.1%)

6 (25%)

 < 0.001*

 Severe sepsis

7 (15.6%)

7 (28%)

 Septic shock

4 (8.9%)

11 (44%)

Complex chronic condition**

15 (32.6%)

11 (45.8%)

0.28

Malnutrition

21 (45.7%)

14 (58.3%)

0.31

Illness severity

ARDSa

1 (2.2%)

8 (32%)

0.001*

Mechanical ventilation

8 (17.8%)

22 (88%)

 < 0.001*

Ventilator-free days

7 (4.5 – 10)

1 (0 – 6)

 < 0.001*

HAIb

6 (13.3%)

12 (48%)

0.001*

Vasoactive medications

4 (8.9%)

17 (68%)

 < 0.001*

Vasoactive infusion days

0 (0 – 0)

4 (0 – 6)

 < 0.001*

Vasoactive-inotropic score (day 1)

0 (0 – 0)

10 (0 – 25)

 < 0.001*

Vasoactive-inotropic score (day 2)

0 (0 – 0)

20 (0 – 30)

 < 0.001*

Need for renal replacement therapy

2 (4.3%)

3 (12.5%)

0.33

MODSc (day1)

6 (13.3%)

14 (56%)

 < 0.001*

MODS (day 3)

2 (4.4%)

14 (56%)

 < 0.001*

PICUd stay, days

7 (5 – 11.5)

7 (4 – 20.5)

0.79

PIM2e mortality risk%

2.2 (1.4 – 6.2)

7.1 (1.8 – 21.1)

0.003*

pSOFAf score (1st day)

4 (3 – 5.8)

8 (5 – 11.5)

 < 0.001*

Laboratory values on admission

CRPg, mg/dL

24 (7.8 – 52.5)

32 (6 – 87.5)

0.72

Hemoglobin, g/dL

10.3 (9.6 – 11.3)

10 (8.8 – 10.8)

0.29

WBCh, 1000/uL

15.7 (9.9 – 20.0)

13.1 (4.1 – 22.4)

0.52

ANCi, 1000/uL

8.9 (5.9 – 13.5)

9.9 (2.3 – 16.1)

0.97

Platelets, 1000/uL

349.5 (175.5 – 424.5)

210.5 (82.8 – 346.5)

0.024*

Creatinine, mg/dL

0.55 (0.4 – 0.7)

0.65 (0.5 – 1.28)

0.14

ALTj, U/L

21 (15 – 39.3)

26.5 (18 – 99.5)

0.13

ADAMTS-13 k, ng/mL

2.45 (0.98 – 3.50)

0.9 (0.80 – 1.18)

 < 0.001*

  1. Data is presented as median (interquartile range) or number (%)
  2. aAcute Respiratory Distress Syndrome
  3. bHospital-acquired infections
  4. cMultiple Organ Dysfunction Syndrome
  5. dPediatric Intensive Care Unit
  6. ePediatric Index of Mortality2
  7. fpediatric Sequential Organ Failure Assessment score
  8. gC-reactive protein
  9. hWhite blood cell Count
  10. iAbsolute neutrophil count
  11. jAlanine aminotransferase
  12. ka disintegrin-like and metalloprotease with thrombospondin type 1 motif, 13
  13. *Statistically significant
  14. **Defined as chronic diseases that result in medical fragility, functional limitations, and substantial health care needs