From: ADAMTS13 in pediatric sepsis: a prognostic biomarker with potential therapeutic implications
Variable | Survivors (n = 46) | Non-survivors (n = 24) | p-value |
---|---|---|---|
General characteristics | |||
Age, month | 12 (4 – 48) | 18 (6.5 – 102) | 0.19 |
Male sex | 20 (44.4%) | 11 (44%) | 0.97 |
Weight, Kg | 8.6 (5.5 – 12.8) | 8 (6.3 – 21) | 0.32 |
Category | |||
Sepsis | 35 (76.1%) | 6 (25%) | < 0.001* |
Severe sepsis | 7 (15.6%) | 7 (28%) | |
Septic shock | 4 (8.9%) | 11 (44%) | |
Complex chronic condition** | 15 (32.6%) | 11 (45.8%) | 0.28 |
Malnutrition | 21 (45.7%) | 14 (58.3%) | 0.31 |
Illness severity | |||
ARDSa | 1 (2.2%) | 8 (32%) | 0.001* |
Mechanical ventilation | 8 (17.8%) | 22 (88%) | < 0.001* |
Ventilator-free days | 7 (4.5 – 10) | 1 (0 – 6) | < 0.001* |
HAIb | 6 (13.3%) | 12 (48%) | 0.001* |
Vasoactive medications | 4 (8.9%) | 17 (68%) | < 0.001* |
Vasoactive infusion days | 0 (0 – 0) | 4 (0 – 6) | < 0.001* |
Vasoactive-inotropic score (day 1) | 0 (0 – 0) | 10 (0 – 25) | < 0.001* |
Vasoactive-inotropic score (day 2) | 0 (0 – 0) | 20 (0 – 30) | < 0.001* |
Need for renal replacement therapy | 2 (4.3%) | 3 (12.5%) | 0.33 |
MODSc (day1) | 6 (13.3%) | 14 (56%) | < 0.001* |
MODS (day 3) | 2 (4.4%) | 14 (56%) | < 0.001* |
PICUd stay, days | 7 (5 – 11.5) | 7 (4 – 20.5) | 0.79 |
PIM2e mortality risk% | 2.2 (1.4 – 6.2) | 7.1 (1.8 – 21.1) | 0.003* |
pSOFAf score (1st day) | 4 (3 – 5.8) | 8 (5 – 11.5) | < 0.001* |
Laboratory values on admission | |||
CRPg, mg/dL | 24 (7.8 – 52.5) | 32 (6 – 87.5) | 0.72 |
Hemoglobin, g/dL | 10.3 (9.6 – 11.3) | 10 (8.8 – 10.8) | 0.29 |
WBCh, 1000/uL | 15.7 (9.9 – 20.0) | 13.1 (4.1 – 22.4) | 0.52 |
ANCi, 1000/uL | 8.9 (5.9 – 13.5) | 9.9 (2.3 – 16.1) | 0.97 |
Platelets, 1000/uL | 349.5 (175.5 – 424.5) | 210.5 (82.8 – 346.5) | 0.024* |
Creatinine, mg/dL | 0.55 (0.4 – 0.7) | 0.65 (0.5 – 1.28) | 0.14 |
ALTj, U/L | 21 (15 – 39.3) | 26.5 (18 – 99.5) | 0.13 |
ADAMTS-13 k, ng/mL | 2.45 (0.98 – 3.50) | 0.9 (0.80 – 1.18) | < 0.001* |