Impact of methods of estimating baseline Serum Creatinine (bSCr) on the incidence and outcomes of acute kidney injury in childhood severe malaria

Egyptian Pediatric Association Gazette

Table 4 Hospitalization outcomes (death) among severe malaria AKI based on the two methods

Variable	Total	Discharge	Death	Mortality rate	OR	Test		p-value
Total	541	508	33	6.1
No AKI (Pottel)	304	290	14	4.6		2.706	0.100
AKI (Pottel)	237	218	19^a	8.0
No AKI (Schwartz)	333	316	17	5.1		1.496	0.0221
AKI (Schwartz)	208	192	16^a	7.7
AKI stages (Pottel) 1	178	169	9	5.1	1			0.002
2	31	28	3	9.7	2.012	0.513, 7.890		0.316
3	28	21	7	25.0	6.259	2.111, 18.558		0.001
AKI stages (Schwartz)	166	158	8	4.8	1
2	24	21	3	12.5	2.821	0.694, 11.474		0.147
3	18	13	5	27.8	7.596	2.171, 26.575		0.002
Age (Pottel)	Pottel
< 5 years	133	123	10	7.5	1
5 to 10 years	80	73	7	8.8	1.179	(0.430, 3.233),		0.748
> 10 years	24	22	2	8.3	1.118	(0.229, 5.453),		0.890
Age (Schwartz)
< 5 years	118	110	8	6.8	1
5 to 10 years	68	62	6	8.8	1.331	(0.441, 4.011)		0.612
> 10 years	22	20	2	9.1	1.375	(0.272, 6.956)		0.700
Correlation						Spearman’s rho
Pottel AKI stages^b						0.207		0.001
Schwartz AKI stages^b						0.227		0.001
Pottel vs Schwartz^c						0.914		< 0.001

CI Confidence interval
^achi-square for comparing mortality between the two methods = 19.638, p < 0.001
^bVs mortality
^cMortality rate by both methods. K-Kappa’s statistics- K = 0.819, (95% CI 0.627 to 1.000)