Table 6 Frequency of NOD2 rs2066845 genotype and allelic polymorphisms among asthmatic cases compared to controls with their statistical significance

Family history

(0.066)

8.8

    Positive (19)

0 (0)

2 (10.5)

17 (89.5)

2 (5.3)

36(94.7)

(0.003*)

    Control (39)

9 (23.1)

5 (12.8)

25 (64.1)

23(29.5)

55 (70.5)

Parental smoking

(0.017*)

6.7

    Positive (51)

2 (3.9)

10(19.6)

39 (76.5)

14(13.7)

88(86.3)

(0.009*)

    Control (39)

9 (23.1)

5 (12.8)

25 (64.1)

23(29.5)

55 (70.5)

Allergic rhinitis

(≤ 0.001**)

13.3

    Positive (59)

0 (0)

11(18.6)

48 (81.4)

11 (9.3)

107(90.7)

(≤ 0.001**)

    Control (39)

9 (23.1)

5 (12.8)

25 (64.1)

23(29.5)

55 (70.5)

Atopic dermatitis

(0.001*)

15.3

    Positive (49)

0 (0)

7 (14.3)

42 (85.7)

7 (7.1)

91 (92.9)

(≤ 0.001**)

    Control (39)

9 (23.1)

5 (12.8)

25 (64.1)

23(29.5)

55 (70.5)