Table 5 Frequency of NOD2 rs2066845 genotype and allelic polymorphisms among asthmatic phenotypes compared to controls
NOD2 rs2066845 | Allergic march (n = 45) | Cough phenotype group (n = 54) | Control group (n = 39) | Test of significance | ||
|---|---|---|---|---|---|---|
P1 | P2 | P3 | ||||
Genotype frequency | 0.003* | 0.014* | 0.277 | |||
CC | 0 (0%) | 2 (3.1%) | 9 (23.1%) | |||
GC | 7 (15.6%) | 12 (18.8%) | 5 (12.8%) | |||
GG | 38 (84.4%) | 40 (62.5%) | 25 (64.1%) | |||
Allele frequency | ≤ 0.001* | 0.015* | 0.123 | |||
C (r) | 7 (7.8%) | 16 (14.8%) | 23 (29.5%) | |||
G | 83 (92.2%) | 92 (85.2%) | 55 (70.5%) | |||
OR (95%CI) | 4.9 (1.9–12.3) | 2.4 (1.2–4.9) | (r) | – | – | – |