Prevalence of bronchial asthma and correlation between the chemokine receptor 3 gene polymorphism and clinical asthma phenotypes among Egyptian asthmatic children

Egyptian Pediatric Association Gazette

Table 7 Association of CCR3 T51C genotypes among the studied asthmatic phenotypes

CCR3 T51C	Cough phenotype N (%)	Cough with allergic rhinitis phenotype N (%)	Cough and wheeze phenotype N (%)	OR	CI (95%)	P value
TT (mutant type)	13 (65)	13 (65)	10 (50)	OR_1,2 = 0.75 OR_1,3 = 2.6 OR_2,3 = 5.2	CI_1,2 = 0.30–1.82 CI_1,3 = 0.51–5.55 CI_2,3 = 0.5–54.0	P_1,2 = 0.6 P_1,3 = 0.3 P_2,3 = 0.1
CT (heterozygous)	5 (25)	6 (30)	6 (30)	OR_1,2 = 0.68 OR_1,3 = 1.6 OR_2,3 = 4.00	CI_1,2 = 0.24–1.90 CI_1,3 = 0.14–25.2 CI_2,3 = 0.3–47.11	P_1,2 = 1.0 P_1,3 = 1.0 P_2,3 = 0.5
CC (r) (wild type)	2 (10)	1 (5)	4 (20)	1	–	–

r reference group
^*statistical significance was defined as P < 0.05
The above table showed that there was higher association of CCR3 T51C among studied asthmatic phenotypes as regards TT than CT without statistically significant difference (P > 0.05)