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Table 4 Demographic and clinical features of different clinical asthma phenotypes

From: Prevalence of bronchial asthma and correlation between the chemokine receptor 3 gene polymorphism and clinical asthma phenotypes among Egyptian asthmatic children

Asthma phenotypes

 

Cough asthma phenotype n = 20

Cough with allergic rhinitis phenotype n = 20

Cough and Wheeze phenotype n = 20

Test of significance

P value

Age in years mean ± SD

9 ± 3.5

9.3 ± 3.4

8.9 ± 3.2

0.06

0.9

Duration of asthma in years

5.5 (1–11)

5.5 (2–12)

5.5 (3–13)

1.06

0.5

Gender no. %

 Male

14 (70)

16 (80)

8 (40)

χ2 = 7.4

0.02*

 Female

6 (30)

4 (20)

12 (60)

Residence no. %

 Rural

14 (70)

8 (40)

10 (50)

χ2 = 3.7

0.1

 Urban

6 (30)

12 (60)

10 (50)

Crowding Index no. %

 ≤ 2 persons/room

13 (65)

13 (65)

14 (70)

χ2 = 0.1

0.9

 > 2 persons/room

7 (35)

7 (35)

6 (30)

Family history of allergic diseases no. %

 Yes

5 (25)

10 (50)

7 (35)

χ2 = 2.7

0.2

 No

15 (75)

10 (50)

13 (65)

History of allergic rhinitis no. %

 Yes

4 (20)

20 (100)

8 (40)

χ2 = 27.8

 > 0.001*

 No

16 (80)

0 (0)

12 (60)

History of atopic dermatitis no. %

 Yes

3 (15)

9 (45)

10 (50)

χ2 = 6.17

0.04*

 No

17 (85)

11 (55)

10 (50)

Family history of smoking no. %

 Yes

8 (40)

7 (35)

12 (60)

χ2 = 2.8

0.2

 No

12 (60)

13 (65)

8 (40)

Parental consanguinity no.%

 Yes

4 (20)

4 (20)

5 (25)

χ2 = 0.19

0.9

 No

16 (80)

16 (80)

15 (75)

Type of feeding during infancy no. %

 Breast feeding

11 (55)

10 (50)

11 (55.5)

χ2 = 5.7

0.2

 Formula feeding

2 (10)

0 (0)

4 (20)

 Mixed

7 (35)

10 (50)

5 (25)

  1. *P value less than 0.05 is considered statistically significant
  2. *χ2 chi-square test
  3. Cough phenotype and cough with allergic rhinitis phenotype showed a significant male predominance, while cough and wheeze phenotype showed a significant female predominance (p value = 0.02). History of allergic rhinitis was significantly higher in cough and allergic rhinitis phenotype (p value = 0.001). Cough asthma phenotype significantly were not have history of atopic dermatitis when compared with others phenotypes (p value = 0.04)