Growth hormone therapy response in children with short stature

Egyptian Pediatric Association Gazette

Table 2 Comparison of anthropometric parameters, mean GH dose and mean height gain after 1 year GH therapy (no. = 40)

Characteristics (after 1^st year of GH therapy)	IGHD (n = 21) (Mean ± SD)	ISS (n = 8) (Mean ± SD)	SGA (n = 11) (Mean ± SD)	p value
Age (years)	13.56 ± 2.71	14.75 ± 3.52	12.34 ± 2.99	0.16
Height(cm)	135.26 ± 13.67	138.7 ± 16.78	128 ± 15.84	0.308
Height SD	-3.12 ± 0.75	-3.095 ± 0.78	-3.27 ± 0.92	0.976
Mean GH dose during the 1^st year (mg/kg/day)	0.04 ± 0.01	0.042 ± 0.02	0.039 ± 0.01	0.712
Mean height gain during the 1^st year (cm/year)	6.595 ± 2.39	4.63 ± 2.36	4.46 ± 2.14	0.039**
Δ height SD after 1^st year of GH therapy	0.34 ± 0.42	0.3 ± 0.45	0.15 ± 0.37	0.42

1^st First, SD Standard deviation, cm Centimetre, MPH Mid-parental height, GH Growth hormone, mg Milligram, cm Centimetre, Δ height SD Height SD after 1 year-initial height SD, IGHD Idiopathic growth hormone deficiency, ISS Idiopathic short stature, SGA Small for gestational age
^**significant p value, 0.05