Table 1 Pediatric cases diagnosed with relapse presenting as aleukemic leukemia cutis

1

Joshi K, et al. [6]

2

Pre-B-ALL

The patient was diagnosed with pre-B ALL (isolated bone marrow involvement) at the age of two. ALC was identified on the 28th day of the BFM protocol while the bone marrow was in remission. The patient developing bone marrow and testicular relapse died in the second month of the BFM relapse protocol.

2

Shahriari et al. [1]

8

T-cell ALL

The patient was diagnosed with T-ALL (isolated bone marrow involvement) at the age of eight. ALC relapse (hard palate, lips, and skin) was identified two years following the completion of the treatment. Prognosis: lesions regressed in the second week after chemotherapy and the patient became a transplant candidate.

3

Mohammadi Ashiani et al. [9]

9

Pre-B-ALL

The patient was diagnosed with pre-B ALL (bone marrow involvement and ulcerated lesions on the skin) at the age of five and with testicular and bone marrow relapse at the age of nine. During the ALL-REZ BFM protocol, isolated LC was identified on the face following the R1-R2 block. No information about the prognosis was provided.

4

Pavon-Mengual M, et al. [10]

10

common B lineage ALL

At the age of 10, isolated skin relapse was identified 22 months after the B-ALL treatment was completed. Prognosis: lesions regressed in the second week after chemotherapy. No information about the prognosis was provided.