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Table 4 Summary of studies on suPAR in relation to progression of renal failure

From: Soluble urokinase plasminogen activator receptor (suPAR) and glomerular disease in children: a narrative review

Year Study N. cases Patient population suPAR (pg/ml) Comments
2017 Schaefer et al. [32] 898 The mean age was 11.9 years old, 62.4% male.
Follow-up of the study for 7.9 years, mean 3.1 years. The end of follow-up when glomerular filtration rate decreases by more than 50% for more than 1 month, or <10ml/min/1.73m2, or start renal replacement.
5658 The 5-year renal survival rate was 64.5% (95% CI, 57.4–71.7) in children with suPAR concentration in the lowest quartile compared with 35.9% (95% CI, 28.7–43.0) of suPAR concentration in the highest quartile (p < 0.001).
2020 Weideman et al. [22] 556 Age from 1 to 16 years old.
6-month follow-up
3204 (i) Patients with suPAR in the highest quartile had a 54% faster progression than the group in the lowest quartile (p < 0.001)
(ii) No change in plasma suPAR level in 6 months
(iii) The higher the suPAR concentration, the faster progression to chronic kidney disease.
2020 Iversen et al. [23] 25,497 Mean age: 58 years old, 52.5% female   Serum suPAR was a risk factor for acute and chronic renal failure. suPAR was a potential marker to classify the risk of renal injury with the intention of early intervention.
2021 Jhee et al. [33] 751 Mean age: 61.4± 11.4 years old with 52.6% male 1439 suPAR concentration was an independent factor associated with progression of chronic kidney disease.
2020 Roca et al. [34] 152 Mean age: 46–50 years old 3160–4347 There was an inverse relationship between glomerular filtration rate with serum suPAR (rs= −0.39, p<0.01).
2021 Jehn et al. [35] 100 Kidney transplant patients after 1 year follow-up   suPAR concentration above 6212 pg/ml were associated with a reduction of glomerular filtration rate >30% and occurred almost twice as rapidly as in patients with suPAR ≤6212 pg/ml (p < 0.001).