Table 4 Summary of studies on suPAR in relation to progression of renal failure
Year | Study | N. cases | Patient population | suPAR (pg/ml) | Comments |
|---|---|---|---|---|---|
2017 | Schaefer et al. [32] | 898 | The mean age was 11.9 years old, 62.4% male. Follow-up of the study for 7.9 years, mean 3.1 years. The end of follow-up when glomerular filtration rate decreases by more than 50% for more than 1 month, or <10ml/min/1.73m2, or start renal replacement. | 5658 | The 5-year renal survival rate was 64.5% (95% CI, 57.4–71.7) in children with suPAR concentration in the lowest quartile compared with 35.9% (95% CI, 28.7–43.0) of suPAR concentration in the highest quartile (p < 0.001). |
2020 | Weideman et al. [22] | 556 | Age from 1 to 16 years old. 6-month follow-up | 3204 | (i) Patients with suPAR in the highest quartile had a 54% faster progression than the group in the lowest quartile (p < 0.001) (ii) No change in plasma suPAR level in 6 months (iii) The higher the suPAR concentration, the faster progression to chronic kidney disease. |
2020 | Iversen et al. [23] | 25,497 | Mean age: 58 years old, 52.5% female | Â | Serum suPAR was a risk factor for acute and chronic renal failure. suPAR was a potential marker to classify the risk of renal injury with the intention of early intervention. |
2021 | Jhee et al. [33] | 751 | Mean age: 61.4± 11.4 years old with 52.6% male | 1439 | suPAR concentration was an independent factor associated with progression of chronic kidney disease. |
2020 | Roca et al. [34] | 152 | Mean age: 46–50 years old | 3160–4347 | There was an inverse relationship between glomerular filtration rate with serum suPAR (rs= −0.39, p<0.01). |
2021 | Jehn et al. [35] | 100 | Kidney transplant patients after 1 year follow-up |  | suPAR concentration above 6212 pg/ml were associated with a reduction of glomerular filtration rate >30% and occurred almost twice as rapidly as in patients with suPAR ≤6212 pg/ml (p < 0.001). |