Table 2 Summary of studies on suPAR related to FSGS
Year | Study | N. cases | Patient population | suPAR (pg/ml) | Comments |
|---|---|---|---|---|---|
2011 | Wei et al. [18] | 78 | Mean age: 27 years old, 60% male | 70%> 3000pg/ml | Be a multi-center research Have control group suPAR> 3000pg/ml accounted for 45/63 patients with FSGS, 4/11 patients with membranous nephritis (MN) and no patient with MCD. |
2012 | Wei et al. (PodoNet and CT ) [26] | 70 | Mean age: 19 years old, 55% male Average age <18 years old | 4588±203/CT 3497 ± 195/ Podonet | Have control group (i) If suPAR # 3000pg/ml was threshold for diagnosis FSGS, 83% of the patients was positive in the CT group and 55.3% of the patients was positive in the PodoNet group. (ii) The inflammation was not a compatible factor for increasing suPAR concentrations in FSGS |
2013 | 74 | Mean age: 29 years old, 68% male | 2923 | Be a multi-center research (i) suPAR concentration in the FSGS group significantly increased compared to MCD (mean: 2050 pg/ml) and MN (mean: 2029 pg/ml) (ii) Plasma suPAR concentration did not differentiate primary and secondary FSGS | |
2016 | Chen et al. [28] | 40 | 18 patients with FSGS and 22 patients with MCD Mean age > 18 years old |  | suPAR concentration in FSGS (3670±170 ng/ml) was significantly higher than suPAR concentration in MCD (2030 ± 180 ng/ml). |
2018 | Verdelho et al. [19] | 90 | Mean age: 49 years old, 61% female 61 patients were performed renal biopsy: there were 30 cases with FSGS | Â | Serum suPAR did not help distinguish FSGS from these other histopathological forms. |
2019 | Shuai et al. [29] | Â | A meta-analysis of 29 studies on serum suPAR | 2992.6 to 5500 | suPAR concentration of 3000 pg/ml may be the best threshold for the diagnosis of primary FSGS (sensitivity = 0.72; specificity = 0.88; the area under the curve (AUC) = 0.85). |