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Table 2 Summary of studies on suPAR related to FSGS

From: Soluble urokinase plasminogen activator receptor (suPAR) and glomerular disease in children: a narrative review

Year Study N. cases Patient population suPAR (pg/ml) Comments
2011 Wei et al. [18] 78 Mean age: 27 years old, 60% male 70%> 3000pg/ml Be a multi-center research
Have control group
suPAR> 3000pg/ml accounted for 45/63 patients with FSGS, 4/11 patients with membranous nephritis (MN) and no patient with MCD.
2012 Wei et al. (PodoNet and CT ) [26] 70 Mean age: 19 years old, 55% male
Average age <18 years old
4588±203/CT
3497 ± 195/ Podonet
Have control group
(i) If suPAR # 3000pg/ml was threshold for diagnosis FSGS, 83% of the patients was positive in the CT group and 55.3% of the patients was positive in the PodoNet group.
(ii) The inflammation was not a compatible factor for increasing suPAR concentrations in FSGS
2013 Huang et al. [21, 27] 74 Mean age: 29 years old, 68% male 2923 Be a multi-center research
(i) suPAR concentration in the FSGS group significantly increased compared to MCD (mean: 2050 pg/ml) and MN (mean: 2029 pg/ml)
(ii) Plasma suPAR concentration did not differentiate primary and secondary FSGS
2016 Chen et al. [28] 40 18 patients with FSGS and 22 patients with MCD
Mean age > 18 years old
  suPAR concentration in FSGS (3670±170 ng/ml) was significantly higher than suPAR concentration in MCD (2030 ± 180 ng/ml).
2018 Verdelho et al. [19] 90 Mean age: 49 years old, 61% female
61 patients were performed renal biopsy: there were 30 cases with FSGS
  Serum suPAR did not help distinguish FSGS from these other histopathological forms.
2019 Shuai et al. [29]   A meta-analysis of 29 studies on serum suPAR 2992.6 to 5500 suPAR concentration of 3000 pg/ml may be the best threshold for the diagnosis of primary FSGS (sensitivity = 0.72; specificity = 0.88; the area under the curve (AUC) = 0.85).