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Table 3 Relation between different PTPN22 genotypes and patients’ demographics and clinical data

From: PTPN22 gene and IL2RA rs11594656, rs2104286 gene variants: additional insights of polygenic single-nucleotide polymorphisms’ pattern among Egyptian children with type 1 diabetes

  PTPN22 genotype χ2 P value
TTI
(N = 5)
TCII
(N = 84)
CCIII
(N = 11)
No. % No. % No. %
Age/year
• < 5 years 3 60 16 19.05 2 18.18 1.61 I vs. II = .327
• 5–10 years 1 20 31 36.90 7 63.64   I vs. III = .303
• 10 years 1 20 37 44.05 2 18.18   II vs. III = .064
Sex        FE = 3.24 I vs. II = .135
• Male 5 100 47 55.95 1 9   I vs. III = .058
• Female 0 0 37 44.05 10 91   II vs. III = .052
Family history        FE = 2.85 I vs. II = .211
 Positive 1 20 41 48.80 3 27.27   I vs. III = .787
 Negative 4 80 43 51.19 8 72.72   II vs. III = .180
Consanguinity        FE = 1.23 I vs. II = 0.054
 Positive 4 80 11 13 3 27   I vs. III = 0.061
 Negative 1 20 73 87 8 73   II vs. III = .222
Age of onset/year
• 2 years 3 60 10 11.90 3 27.27 4.13 I vs. II = .020
• > 2–5 years 0 0 13 15.48 2 18.18   I vs. III = .239
• > 5 years 2 40 61 72.62 6 54.55   II vs. III = .162
Presentation of illness         I vs. II = .590
• DKA 52 62 8 73 4 80 1.89 I vs. III = .292
• Classic 32 38 3 27 1 20   II vs. III = .562
Complication: recurrent DKA 3 60 14 16.65 6 54.5 KW = 1.26 I vs. II = .071
I vs. III = .636
II vs. III = .071
  1. DKA diabetic ketoacidosis
  2. *Significant