Table 3 Relation between different PTPN22 genotypes and patients’ demographics and clinical data
PTPN22 genotype | χ2 | P value | ||||||
|---|---|---|---|---|---|---|---|---|
TTI (N = 5) | TCII (N = 84) | CCIII (N = 11) | ||||||
No. | % | No. | % | No. | % | |||
Age/year | ||||||||
• < 5 years | 3 | 60 | 16 | 19.05 | 2 | 18.18 | 1.61 | I vs. II = .327 |
• 5–10 years | 1 | 20 | 31 | 36.90 | 7 | 63.64 | I vs. III = .303 | |
• 10 years | 1 | 20 | 37 | 44.05 | 2 | 18.18 | II vs. III = .064 | |
Sex | FE = 3.24 | I vs. II = .135 | ||||||
• Male | 5 | 100 | 47 | 55.95 | 1 | 9 | I vs. III = .058 | |
• Female | 0 | 0 | 37 | 44.05 | 10 | 91 | II vs. III = .052 | |
Family history | FE = 2.85 | I vs. II = .211 | ||||||
Positive | 1 | 20 | 41 | 48.80 | 3 | 27.27 | I vs. III = .787 | |
Negative | 4 | 80 | 43 | 51.19 | 8 | 72.72 | II vs. III = .180 | |
Consanguinity | FE = 1.23 | I vs. II = 0.054 | ||||||
Positive | 4 | 80 | 11 | 13 | 3 | 27 | I vs. III = 0.061 | |
Negative | 1 | 20 | 73 | 87 | 8 | 73 | II vs. III = .222 | |
Age of onset/year | ||||||||
• 2 years | 3 | 60 | 10 | 11.90 | 3 | 27.27 | 4.13 | I vs. II = .020 |
• > 2–5 years | 0 | 0 | 13 | 15.48 | 2 | 18.18 | I vs. III = .239 | |
• > 5 years | 2 | 40 | 61 | 72.62 | 6 | 54.55 | II vs. III = .162 | |
Presentation of illness | I vs. II = .590 | |||||||
• DKA | 52 | 62 | 8 | 73 | 4 | 80 | 1.89 | I vs. III = .292 |
• Classic | 32 | 38 | 3 | 27 | 1 | 20 | II vs. III = .562 | |
Complication: recurrent DKA | 3 | 60 | 14 | 16.65 | 6 | 54.5 | KW = 1.26 | I vs. II = .071 I vs. III = .636 II vs. III = .071 |