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Table 5 Performance of the studied non-invasive markers in the detection of early (F1–F2) in the studied group

From: Comparative study between liver biopsy and non-invasive biomarkers in assessment of hepatic fibrosis in children with chronic liver diseases

  Cutoff value Sens% Spec% PPV% NPV% AUC 95% CI
APRI > 0.96 46.4% 91.9% 94.7% 32.2% 0.745 0.71–0.82
M-APRI >0.16 61.3% 96.5% 97.9% 40.4% 0.831 0.63–0.88
FIB-4 >0.019 54.8% 94.5% 97.7% 36.9% 0.750 0.55–0.85
M-FIB-4 >0.005 49.7% 96.5% 97.4% 34.4% 0.759 0.64–0.79
B-AST >−8 74.2% 75.7% 90.5% 43.2% 0.758 0.66–0.85
  1. Sens sensitivity, Spec specificity, PPV positive predictive value, NPV negative predictive value, AUC area under the curve, CI confidence interval