Comparative study between liver biopsy and non-invasive biomarkers in assessment of hepatic fibrosis in children with chronic liver diseases

Egyptian Pediatric Association Gazette

Table 4 Correlation between the non-invasive biomarkers and lab investigations and histopathological evaluation in the study group

	APRI		M-APRI		FIB-4		M-FIB-4		B-AST
	Rho	P	Rho	P	Rho	P	Rho	P	Rho	P
Age (years)	0.079	0.27	0.321	0.036	–	–	–	–	0.147	0.18
ALT (IU/L)	0.649	<0.001	0.018	0.85	–	–	–	–	0.018	0.85
T. bilirubin (mg/dL)	0.297	0.003	0.235	0.018	0.156	0.12	0.189	0.059	0.223	0.026
D. bilirubin (mg/dL)	0.314	0.002	0.186	0.67	0.173	0.08	0.167	0.098	0.160	0.11
ALP (IU/L)	0.340	0.001	0.130	0.19	0.223	0.034	0.102	0.31	0.125	0.21
GGT (IU/L)	0.253	0.011	0.107	0.29	0.179	0.074	−0.063	0.63	0.08	0.37
Hb (g/dL)	−0.007	0.94	−0.076	0.45	−0.05	0.62	−0.135	0.18	−0.136	0.18
HAI	0.326	0.001	0.418	<0.001	0.316	0.002	0.343	<0.001	0.327	0.0013
Fibrosis stage	0.568	<0.001	0.629	<0.001	0.473	<0.001	0.537	<0.001	0.473	<0.001

BMI body mass index, ALT alanine aminotransferase, T. bilirubin total bilirubin, D. bilirubin direct bilirubin, ALP alkaline phosphatase, GGT gamma-glutamyl transferase, Hb hemoglobin, HAI histological activity index