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Table 4 Correlation between the non-invasive biomarkers and lab investigations and histopathological evaluation in the study group

From: Comparative study between liver biopsy and non-invasive biomarkers in assessment of hepatic fibrosis in children with chronic liver diseases

  APRI M-APRI FIB-4 M-FIB-4 B-AST
Rho P Rho P Rho P Rho P Rho P
Age (years) 0.079 0.27 0.321 0.036 0.147 0.18
ALT (IU/L) 0.649 <0.001 0.018 0.85 0.018 0.85
T. bilirubin (mg/dL) 0.297 0.003 0.235 0.018 0.156 0.12 0.189 0.059 0.223 0.026
D. bilirubin (mg/dL) 0.314 0.002 0.186 0.67 0.173 0.08 0.167 0.098 0.160 0.11
ALP (IU/L) 0.340 0.001 0.130 0.19 0.223 0.034 0.102 0.31 0.125 0.21
GGT (IU/L) 0.253 0.011 0.107 0.29 0.179 0.074 −0.063 0.63 0.08 0.37
Hb (g/dL) −0.007 0.94 −0.076 0.45 −0.05 0.62 −0.135 0.18 −0.136 0.18
HAI 0.326 0.001 0.418 <0.001 0.316 0.002 0.343 <0.001 0.327 0.0013
Fibrosis stage 0.568 <0.001 0.629 <0.001 0.473 <0.001 0.537 <0.001 0.473 <0.001
  1. BMI body mass index, ALT alanine aminotransferase, T. bilirubin total bilirubin, D. bilirubin direct bilirubin, ALP alkaline phosphatase, GGT gamma-glutamyl transferase, Hb hemoglobin, HAI histological activity index