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Table 3 Duration of nephrotic syndrome, steroid therapy, laboratory, and echocardiographic data in cases with systolic dysfunction vs. cases without

From: Hypoalbuminemia linked to myocardial dysfunction in recent-onset nephrotic syndrome: a cross-sectional case control 3DSTE study

  Nephrotic syndrome with impaired GLS (n = 17) Nephrotic syndrome with normal GLS (n = 23) P-value
Mean ± SD Mean ± SD
Serum creatinine at the time of assessment (mg/dL) 0.8 ± 0.05 0.79 ± 0.04 0.56
Serum urea at the time of assessment (mg/dL) 14 ± 2 12 ± 3 0.66
Serum baseline cholesterol (mg/dL) 226 ± 12 232 ± 10 0.56
Serum cholesterol at the time of assessment (mg/dL) 177 ± 21 173 ± 20 0.72
Serum baseline albumin (gm/dL) 2.2 ± 0.1 2.3 ± 0.2 0.56
Serum albumin at the time of assessement (gm/dL) 2.4 ± 0.3 2.9 ± 0.1 < 0.001
Baseline urine P/C ratio 6 ± 0.9 5 ± 1 0.65
Urine P/C ratio at the time of assessment 3 ± 0.7 1.4 ± 0.4 < 0.001
Duration from onset of NS to time of assessment by echocardiography (weeks) 16 ± 1 14 ± 2 0.39
Duration of steroid therapy (weeks) 14.8 ± 2 15.9 ± 3 0.5
Dose of steroid (mg/kg/day) 2 ± 0 2 ± 0 0.9
Weight difference from the onset to time of assessment (kg) 2.2 ± 0.2 3.1 ± 0.3 < 0.001
3D LVEDV (ml) 61 ± 12 58 ± 22 0.45
3D EF (%) 77 ± 3.2 79 ± 4 0.40
FS (%) 46 ± 2 46 ± 3 0.23
GLS (%) 14 ± 3.2 18 ± 1.41 < 0.0001
E/e′ 12 ± 2 8 ± 1.29 < 0.0001
  1. Abbreviations: E/e′ ratio of diastolic function of LV; ratio of early transmitral inflow to average early diastolic velocities of mitral annulus and basal septum, EDV End diastolic volume, EF Ejection fraction, FS Fractional shortening, GLS Global longitudinal strain, LV Left ventricle, n number, P/C ratio protein creatinine ratio, P Pearson’s coefficient for statistical significance
  2. P < 0.05 was considered statistically significant