COVID-19 during pregnancy should we really worry from vertical transmission or rather from fetal hypoxia and placental insufficiency? A systematic review

AbdelMassih, Antoine; Fouda, Raghda; Essam, Rana; Negm, Alhussein; Khalil, Dalia; Habib, Dalia; Afdal, George; Ismail, Habiba-Allah; Aly, Hadeer; Genedy, Ibrahim; El Qadi, Layla; Makki, Leena; Shulqamy, Maha; Hanafy, Maram; AbdelMassih, Marian; Ibrahim, Marina; Ebaid, Mohamed; Ibrahim, Monica; El-Husseiny, Nadine; Ashraf, Nirvana; Shebl, Noura; Menshawey, Rahma; Darwish, Rama; ElShahawi, Rana; Ramadan, Rana; Albala, Sadra; Imran, Salwa; Ahmed, Sama; Khaldi, Samer; Abohashish, Sara; Paulo, Stavro; Omar, Yasmin; Tadros, Mourad Alfy

doi:10.1186/s43054-021-00056-0

Egyptian Pediatric Association Gazette

Table 2 Summary of data in the included studies of vertical transmission of COVID-19

From: COVID-19 during pregnancy should we really worry from vertical transmission or rather from fetal hypoxia and placental insufficiency? A systematic review

Reference number in the text	Reference	Type of the study	Number of mothers	Number of positive neonates	Number of fetal/neonatal deaths	Cause of fetal death	Placenta examined	Country of origin
[13]	Khan, S. et al.	Case series	17	0	0		0	China
[14]	Hantoushzadeh, S. et al.	Case series	9	0	3	Intrauterine fetal death with 1 case of non-reassuring cardiotocography	0	Iran
[15]	Chen, S. et al.	Case series	5	0	0		0	China
[16]	Chen, R. et al.	Retrospective study	17	0	0		0	China
[17]	Ferrazzi, E. et al.	Retrospective study	42	1	0		0	Italy
[18]	Dashraath, P. et al.	Retrospective study	55	0	2	Intrauterine fetal death with preceding intrauterine growth restriction	0	China
[19]	Baud, D. et al.	Case Report	1	0	0		1	Switzerland
[20]	Dong, L. et al.	Case Report	1	1	0		0	China
[21]	González Romero, D., et al	Case Report	1	0	0		0	Spain
[22]	Breslin, N. et al.	Retrospective study	43	0	0		0	USA
[23]	Alzamora, M. C. et al.	Case Report	1	1	0		0	Peru
[24]	Chen, H. et al.	Case series	9	0	0		0	China
[25]	Qiancheng, X. et al.	Retrospective study	82	0	0		0	China
[26]	Liu, Y., et al	Retrospective study	13	0	0		0	China
[27]	Liao, X., et al	Case Report	1	0	0		0	China
[28]	Yu, N. et al.	Case Report	1	1	0		0	China
[29]	Kirtsman, M. et al.	Case series	4	0	0		0	Canada
[30]	Kang, X. et al.	Case Report	1	0	0		0	China
[31]	Buonsenso, D. et al.	Case series	4	0	0		0	China
[32]	Lu, D. et al.	Case Report	1	0	0		0	China
[33]	Khan, S. et al.	Case series	3	0	0		0	China
[34]	Kalafat, E. et al.	Case Report	1	0	0		1	Turkey
[35]	Karami, P. et al.	Case Report	1	0	0		1	Iran
[36]	Nie, R. et al.	Retrospective study	33	1	0		0	China
[37]	Lowe, B. Et al	Case Report	1	0	0		0	Australia
[38]	Chen, S. et al.	Case series	3	0	0		3	China
[39]	Li, Y. et al.	Case series	1	0	0		0	China
[40]	Fan, C. et al.	Case series	2	0	0		2	China
[41]	Zambrano, L. I. et al.	Case Report	1	0	0		0	Honduras
[42]	Iqbal, S. N. et al.	Case Report	1	0	0		0	China
[43]	Wang, X. et al.	Case Report	1	0	0		1	China
[44]	Xiong, X. et al.	Case Report	1	0	0		0	China
[45]	Lee, D. H. et al.	Case Report	1	0	0		0	China
[46]	Yue, L. et al.	Case Report	14	0	0		0	China
[47]	Liu, W. et al.	Retrospective study	19	0	0		0	China
[48]	Shi, H. et al.	Retrospective study	81	0	0		0	China
[49]	Liao, J. et al.	Case Report	1	0	0		1	China
[50]	Yin, M. et al.	Retrospective study	16	0	0		16	China
[51]	Li, N. et al.	Case-Control	34	0	0		0	China
[52]	Shanes, E. D. et al.	Retrospective study	16	0	7	IUGR	16	USA
[53]	Knight Dphil, M. et al.	Retrospective study	420	24	5	2 from neonatal pneumonia and 3 IUFD	0	UK
[54]	Govind, A. et al.	Case series	9	3	0		0	UK
[55]	Kayem, G. et al.	Retrospective study	617	2	1	Not specified	0	France
[56]	Nyholm, S. et al.	Case Report	1	1	0		0	Sweden
[57]	Easterlin, M. C., et al	Case Report	1	0	0		0	USA
[58]	Wu, Y. et al.	Case series	13	0	0		0	China
[59]	Hong, L. et al.	Case Report	1	0	0		0	USA
[60]	Vivanti, A. J. et al.	Case Report	1	0	0		1	France
[61]	Salvatori, G. et al.	Case series	2	2			0	Italy
[62]	Wu, Y.-T. et al.	Retrospective study	29	4			0	China
[63]	Sisman, J. et al.	Case Report	1	1	0		1	USA
[64]	Yang, P. et al.	Case Report	7	0	0		0	China
[65]	Zheng, T. et al.	Case series	2	0	0		0	China
[66]	Wang, S. et al.	Case Report	1	0	0		1	China
[67]	Dumpa, V., et al	Case Report	1	1	0		0	China
[68]	Masmejan, S. et al.	Case series	13	0	0		13	Switzerland
[69]	Yang, H.,et al	Retrospective study	24	1	0		0	China
[70]	Hillary, H. et al.	Case Report	1	0	0		1	USA
[71]	Ferraiolo, A. et al	Case Report	1	0	0		1	Italy
[72]	Ng, W. F. et al.	Case Series	8	0	0		8	Hong Kong
[73]	Edlow, A. G. et al	Case Series	64	0	2	Placental malperfusion	44	USA
[74]	Zeng, H. et al.	Case series	6	0	0		0	China
[75]	Liu, D. et al.	Case series	15	0	0		0	China
[76]	Zhu, H. et al.	Case series	10	0	1	Multiple organ failure and DIC few hours after birth/Small for gestational age	0	China
Totals	-		1787	45	21		112	-

Abbreviations: COVID-19 Coronavirus Disease 2019, DIC Disseminated intravascular coagulation, IUGR Intrauterine growth retardation, IUFD Intrauterine fetal death, UK United Kingdom, USA United States of America

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