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Table 2 Early versus late enteral nutrition

From: Feeding: the hidden variable affecting prognosis of critically ill children

Variable

Early enteral nutrition (≤ 48 h) [n=69]

Late enteral nutrition (> 48 h) [n=126]

P-value

Age, months

36 (7–91)

18 (7.5–60)

0.11

Weight, kg

13 (6–20)

10 (6–16)

0.24

Body mass index

15.6 (13.5–17.7)

15.6 (14.2–18.2)

0.62

Male sex

33 (47.8%)

60 (47.6%)

0.98

Malnutrition

17 (24.6%)

37 (29.4%)

0.48

Complex chronic condition

31 (44.9%)

60 (47.6%)

0.72

Sepsis on admission

29 (42%)

58 (46%)

0.62

Admission pSOFAascore

4 (3–6)

5.5 (4–7)

0.004*

PNbgiven

10 (14.5%)

107 (84.9%)

<0.001*

PICUcMortality

1 (1.4%)

21 (16.7%)

0.001*

PICU stay, days

4 (3–8)

11.5 (6.8–18)

<0.001*

ARDSd

0 (0%)

3 (2.4%)

0.55

Mechanical ventilation

3 (4.3%)

56 (44.4%)

<0.001*

Mechanical ventilation duration, days

0 (0–0)

0 (0–6)

<0.001*

Vasoactive medication use

11 (15.9%)

37 (29.4%)

0.037*

Vasoactive infusion days

0 (0–0)

0 (0–1.3)

0.023*

Hospital-acquired infections

12 (17.4%)

50 (39.7%)

0.001*

Hospital-acquired infection type

 VAPe

0 (0%)

9 (7.1%)

0.001*

 CLABSIf

5 (7.2%)

32 (25.4%)

 VAP+CLABSI**

0 (0%)

5 (4%)

 Others***

7 (10.1%)

4 (3.2%)

Central venous catheter days

0 (0–0)

7 (0–14.5)

<0.001*

Enteral feeding intolerance

8 (11.6%)

26 (20.6%)

0.10

Full enteral caloric intake reached

62 (89.9%)

104 (82.5%)

0.17

Time to full enteral caloric intake, days

1 (1–2)

4 (2.3–6)

<0.001*

  1. Data are expressed as median (interquartile range) or number (%)
  2. *Statistically significant
  3. **VAP+CLABSI means development of VAP and CLABSI in the same patient at different times during PICU stay
  4. ***this Includes urinary tract infections (related to urinary catheterization), gastroenteritis, and local infections at central or peripheral venous catheter sites
  5. aPediatric Sequential Organ Failure Assessment core
  6. bparenteral nutrition
  7. cpediatric intensive care unit
  8. dacute respiratory distress syndrome
  9. eventilator-associated pneumonia
  10. fcentral line-associated blood stream infection