Serum chloride and serum sodium derangements in children on prolonged furosemide therapy and their effect on diuretic response

Egyptian Pediatric Association Gazette

Table 4 Urinary parameters of the included patients

		Hyponatremia	Hypochloremia	Both	Normal	P value	Sig.
		No. = 15	No. = 9	No. = 12	No. = 9	P value	Sig.
Day 1
Urine Na/k	Median (IQR)	1.69 (0.83–2.33)	2.43 (2.77–11.65)	1.65 (0.92–5.89)	1.29 (0.89–2.11)	0.235	NS
Urine Na/k	Range	0.28–4.7	1.18–16.8	0.23–10.3	0.3–2.42	0.235	NS
UOP (ml/kg/h)	Mean ± SD	2.08 ± 0.39	1.88 ± 0.25	1.91 ± 0.56	2.56 ± 0.62	0.055	NS
UOP (ml/kg/h)	Range	1.5–3	1.5–2	1–3	1.5–3	0.055	NS
Net fluid output/40 mg furosemide	Mean ± SD	1401.60 ± 681.09	852.00 ± 126.24	1385.25 ± 770.11	1760 ± 815.84	0.243	NS
Net fluid output/40 mg furosemide	Range	640–2880	720–960	768–2880	640–2880	0.243	NS
Day 3
Urine Na/k	Median (IQR)	3 (2–3.1)	1.95 (1.69–2.5)	1.53 (1.46–1.92)	2.49 (1.6–3)	0.022	S
Urine Na/k	Range	1.49–4.6	1.48–3	1–2.99	1.54–3	0.022	S
UOP (ml/kg/h)	Mean ± SD	4.17 ± 0.68	5.08 ± 1.26	4.80 ± 1.12	4.58 ± 0.60	0.294	NS
UOP (ml/kg/h)	Range	2.5–5	3.5–6.5	3.4–6	3.5–5	0.294	NS
Netfluid output/40 mg furosemide	Mean ± SD	1502.10 ± 518.12	908.33 ± 668.81	562.55 ± 618.43	1808.28 ± 412.79	0.003	HS
Netfluid output/40 mg furosemide	Range	500–2560	320–1760	125.2–2000	1000–2176	0.003	HS