Table 2 Clinical data of included patients at baseline and at day 3 after dose adjustment

Respiratory rate (per minute)

 Day 1

Mean ± SD

52.88 ± 4.29

52.06 ± 6.13

43.61 ± 6.79

51.21 ± 6.17

Range

48–60

40–60

30–55

40–60

 Day 3

Mean ± SD

43.19 ± 5.42

52.17 ± 3.71

40.25 ± 8.47

41.21 ± 9.54

Range

30–52

48–60

25–55

25–55

 p value

0.048

0.956

0.239

0.039

Systolic blood pressure (mmHg)

 Day 1

Mean ± SD

81.75 ± 4.49

81.67 ± 5.69

86 ± 5.77

83.79 ± 6.34

Range

75-90

70-90

80-100

70-90

 Day 3

Mean ± SD

86.75 ± 4.36

84.25 ± 4.85

88.17 ± 6.13

87 ± 7.48

Range

80–90

75–90

80–100

80–100

p value

0.910

0.208

0.334

0.314

Diastolic blood pressure (mmHg)

 Day 1

Mean ± SD

48.13 ± 2.85

49.06 ± 4.89

51.94 ± 4.25

50.64 ± 5.92

Range

45–55

40–60

45–60

40–60

 Day 3

Mean ± SD

51.25 ± 3.42

49.67 ± 4.42

52.5 ± 4.52

53.21 ± 5.04

Range

45–60

45–60

45–60

45–60

 p value

0.217

0.730

0.735

0.141

Capillary refilling time (seconds)

Day 1

2

5 (33.3%)¹

6 (66.6%)

6 (50%)

6 (66.7%)

3

10 (66.7%)

3 (33.3%)

6 (50%)

3 (33.3%)

4

0%

0%

0%

0%

Day 3

2

7 (46.7%)

5 (55.5%)

5 (41.7%)

5 (55.5%)

3

8 (53.3%)

4 (44.4%)

7 (58.3%)

4(44.4%)

4

0%

0%

0%

0%

p value

0.105

0.232

0.279

0.070

Ross classification

Day 1

I

0%

0%

0%

0%

II

0%

0%

6 (50.0%)

0%

III

5 (33.3%)

5 (55.5%)

3(25%)

6 (66.7%)

IV

10 (66.7%)

4 (44.4%)

3 (25%)

3 (33.3%)

Day 3

I

6(40%)

0%

0%

2 (22.2%)

II

6(40%)

0%

5 (42.7%)

3 (33.3%)

III

3(20%)

6 (66.6%)

4 (33.3%)

4 (44.4%)

IV

0%

3 (33.3%)

3(25%)

0%

p value

0.038

0.063

0.794

0.051

Cardiothoracic ratio

Day 1

Mean ± SD

0.56 ± 0.03

0.55 ± 0.04

0.53 ± 0.03

0.55 ± 0.04

Range

0.5–0.6

0.5–0.6

0.49–0.58

0.5–0.6

Day 3

Mean ± SD

0.53 ± 0.03

0.56 ± 0.03

0.54 ± 0.02

0.53 ± 0.03

Range

0.5–0.58

0.52–0.6

0.5–0.58

0.49–0.58

p value

0.476

0.193

0.198

0.574

Lung congestion

Day 1

Mild

3 (20%)

2 (22.2%)

0%

2 (22.2%)

Moderate

7 (46.7%)

6 (66.7%)

9 (77.8%)

5 (55.6%)

Severe

5 (33.3%)

1 (11.1%)

3 (22.2%)

2(22.2%)

Day 3

Mild

11 (73².3%)

2 (22.2%)

0%

6(66.7%)

Moderate

4 (26.7%)

5 (55.5%)

8 (66.7%)

3 (33.3%)

Severe

0%

2 (22.2%)

4 (33.3%)

0%

p value

0.544

0.262

0.500

0.258