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Table 2 Genotype distribution and allele frequency of PTPN22 gene, IL2RA rs11594656, and IL2RA rs2104286 polymorphisms among the studied patients and control groups

From: PTPN22 gene and IL2RA rs11594656, rs2104286 gene variants: additional insights of polygenic single-nucleotide polymorphisms’ pattern among Egyptian children with type 1 diabetes

  T1DM group
(N = 100)
Control group
(N = 100)
Chi-square
(χ2)
P value
No. % No. %
PTPN22 gene       0.028*
- TT (homozygous) 5 5.00 0 0.0 6.20  
- TC (heterozygous) 84 84.0 60 60.0   
- CC (wild variant) 11 11.0 40 40.0   
Alleles (frequency number)       0.038*
OR(95%CI)
3.16(1.28-7.09)
- T 94 47.00 60 30.00 4.11
- C 106 53.00 140 70.00  
IL2RA rs11594656       0.045*
- TT (homozygous) 20 20.0 4 4.00 3.67  
- TA (heterozygous) 60 60.0 60 60.00   
- AA (wild variant) 20 20.0 36 36.00   
Alleles (frequency number)      2.08 0.059
- T 100 50.00 68 34.00   OR(95%CI)
2.38(1.49-6.12)
- A 100 50.00 132 66.00  
IL2RA rs2104286
- AA (homozygous) 60 60.0 57 57.00 0.73 0.091
- AG (heterozygous) 36 36.0 36 36.00   
- GG (wild variant) 4 4.0 7 7.00   
Alleles (frequency number)      0.86 0.089
OR(95%CI)
0.48(0.19-1.18)
- A 156 78.00 150 75.00  
- G 44 22.00 50 25.00  
  1. PTPN22 protein tyrosine phosphatase, non-receptor type 22; IL2RA interleukin 2 receptor alpha subunit
  2. *Significant