Table 2 Genotype distribution and allele frequency of PTPN22 gene, IL2RA rs11594656, and IL2RA rs2104286 polymorphisms among the studied patients and control groups
T1DM group (N = 100) | Control group (N = 100) | Chi-square (χ2) | P value | |||
|---|---|---|---|---|---|---|
No. | % | No. | % | |||
PTPN22 gene | 0.028* | |||||
- TT (homozygous) | 5 | 5.00 | 0 | 0.0 | 6.20 | |
- TC (heterozygous) | 84 | 84.0 | 60 | 60.0 | ||
- CC (wild variant) | 11 | 11.0 | 40 | 40.0 | ||
Alleles (frequency number) | 0.038* OR(95%CI) 3.16(1.28-7.09) | |||||
- T | 94 | 47.00 | 60 | 30.00 | 4.11 | |
- C | 106 | 53.00 | 140 | 70.00 | ||
IL2RA rs11594656 | 0.045* | |||||
- TT (homozygous) | 20 | 20.0 | 4 | 4.00 | 3.67 | |
- TA (heterozygous) | 60 | 60.0 | 60 | 60.00 | ||
- AA (wild variant) | 20 | 20.0 | 36 | 36.00 | ||
Alleles (frequency number) | 2.08 | 0.059 | ||||
- T | 100 | 50.00 | 68 | 34.00 | OR(95%CI) 2.38(1.49-6.12) | |
- A | 100 | 50.00 | 132 | 66.00 | ||
IL2RA rs2104286 | ||||||
- AA (homozygous) | 60 | 60.0 | 57 | 57.00 | 0.73 | 0.091 |
- AG (heterozygous) | 36 | 36.0 | 36 | 36.00 | ||
- GG (wild variant) | 4 | 4.0 | 7 | 7.00 | ||
Alleles (frequency number) | 0.86 | 0.089 OR(95%CI) 0.48(0.19-1.18) | ||||
- A | 156 | 78.00 | 150 | 75.00 | ||
- G | 44 | 22.00 | 50 | 25.00 | ||