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Table 6 Performance of the studied non-invasive biomarkers in the detection of advanced liver fibrosis (F3–F4) in the studied group

From: Comparative study between liver biopsy and non-invasive biomarkers in assessment of hepatic fibrosis in children with chronic liver diseases

  Cutoff value Sens% Spec% PPV% NPV% AUC 95% CI
APRI >1.96 89.9% 84.5% 34.8% 98.7% 0.849 0.76–0.92
M-APRI >2.2 87.8% 96.6% 72.7% 98.9% 0.958 0.92–0.98
FIB-4 >0.045 78.8% 85.6% 33.3% 97.5% 0.853 0.77–0.91
M-FIB-4 >0.015 89.8% 82.4% 32% 98.7% 0.896 0.84–0.97
B-AST >92.1 89.8% 91.2% 47.1% 98.8% 0.955 0.875–0.97
  1. Sens sensitivity, Spec specificity, PPV positive predictive value, NPV negative predictive value, AUC area under the curve, CI confidence interval