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Table 4 Duration of nephrotic syndrome, steroid therapy, laboratory, and echocardiographic data in cases with diastolic dysfunction dysfunction vs. cases without

From: Hypoalbuminemia linked to myocardial dysfunction in recent-onset nephrotic syndrome: a cross-sectional case control 3DSTE study

  Nephrotic syndrome with impaired diastolic function (n = 18) Nephrotic Syndrome with normal diastolic function (n = 22) P-value
Mean ± SD Mean ± SD
Serum creatinine at the time of assessment (mg/dL) 0.79 ± 0.04 0.8 ± 0.04 0.44
Serum urea at the time of assessment (mg/dL) 14 ± 1.9 12 ± 3.1 0.65
Serum baseline cholesterol (mg/dL) 229 ± 11 231 ± 10 0.43
Serum cholesterol at the time of assessment (mg/dL) 175 ± 193 175 ± 19 0.78
Serum baseline albumin (gm/dL) 2.1 ± 0.2 2.2 ± 0.2 0.59
Serum albumin at the time of assessement (gm/dL) 2.4 ± 0.2 2.8 ± 0.1 < 0.001
Baseline urine P/C ratio 6 ± 0.8 5.2 ± 0.5 0.68
Urine P/C ratio at the time of assessment 2.9 ± 0.6 1.5 ± 0.3 < 0.001
Duration from onset of NS to time of assessment by echocardiography (weeks) 14.9 ± 2 15.9 ± 1 0.07
Duration of steroid therapy (weeks) 15 ± 2 12 ± 1 0.44
Dose of steroid 2 ± 0 2 ± 0 0.78
Weight difference from the onset to time of assessment (kg) 2.3 ± 0.3 3.1 ± 0.3 < 0.001
3D LVEDV (ml) 60 ± 8 59 ± 13 0.42
3D EF (%) 78 ± 2.5 79 ± 3.1 0.33
FS (%) 46 ± 3 46 ±2 0.39
GLS (%) 15 ± 3.2 19 ± 1.41 < 0.0001
E/e′ 13±3 8±2 < 0.0001
  1. Abbreviations: E/e′ ratio of diastolic function of LV; ratio of early transmitral inflow to average early diastolic velocities of mitral annulus and basal septum, EF Ejection fraction, FS Fractional shortening, GLS Global longitudinal strain, LV Left ventricle, n number, P Pearson’s coefficient for statistical significance
  2. P < 0.05 was considered statistically significant