From: Practical approach to COVID-19: an Egyptian pediatric consensus
a. Doses of anticoagulation | ||
 | Prophylaxis | Therapeutic dose |
 Heparin | 100–150 units/kg IV once | Infusion • < 1 year—loading dose of 75 units/kg IV, then 28 units/kg/h IV as initial maintenance dose • 1 year—Loading dose of 75 units/kg IV, then 20 units/kg/h IV as initial maintenance dose Intermittent IV injection • Initially give 50–100 units/kg IV infusion, then 100 units/kg IV infusion q4hr as a maintenance dose |
 Enoxaparin | < 2 months: 0.75 mg/kg SC q12h ≥ 2 months: 0.5 mg/kg SC q12hr | < 2 months: 1.5 mg/kg SC q12h ≥ 2 months: 1 mg/kg SC q12hr |
b. Indications and contraindications of anticoagulation | ||
 Indications for prophylactic anticoagulation | All admitted patients with moderate COVID-19, i.e., any patient with pneumonia All moderate and severe cases who don't meet the therapeutic indications | |
 Indications for therapeutic anticoagulation | All ICU patients O2 sat < 92% or tachypnea for age O2 requirements ≥ 4 L on nasal cannula Elevated D-dimer 3x upper level of normal Elevated CRP | |
 Contraindications | Patients who are at high risk of bleeding Platelets < 50,000 INR > 1.5 Active bleeding |