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Table 2 Pediatric drug doses of used medications

From: Practical approach to COVID-19: an Egyptian pediatric consensus

Drug Pediatric Dose Notes
Azithromycin 10 mg/kg once on day 1 (maximum dose: 500 mg/dose) , followed by 5 mg/kg (maximum dose: 250 mg/dose) once daily on days 2 to 5 • Monitor ECG in high risk patients due to the risk of QTc prolongation.
• For 5 days
Ceftriaxone 100 mg/kg/dose once daily (maximum daily dose: 2gm mg/day) • For 5-10 days
Ribavirine children> 3 years of age: 15 mg/kg /day in 2 divided oral doses • Patients with impaired renal function, adjust ribavirine dose according to nephrologist advice.
• Monitor CBC, serum creatinine, liver function
• For 14 days
Lopinavir/ Ritonavir Dosage based on weight, presented based on mg of lopinavir; maximum dose: Lopinavir 400 mg/ritonavir 100 mg 7–15 kg: 12 mg/kg twice daily 15–40 kg: 10 mg/kg twice daily >40 kg: 400 mg/100 mg twice daily • Do not use lopinavir/ ritonavir in pre-term or full term neonates before 14 days of age.
• Check for drug-drug interaction (consult clinical pharmacist).
• If lopinavir/ritonavir is not available may consider darunavir/cobicistat as an alternative.
• For 14 days
Hydroxychloroquine 6.5 mg/kg orally every 12 hours (max: 600 mg/dose) for two doses, followed by 3 mg/kg orally every 12 hours (max: 200 mg/dose) for a total of 5-10 days • Check contraindications carefully
Contraindication : • Use with caution in QT interval prolongation
Allergy to 4-aminoquinoline • Pediatric dose may change based on future studies
Chronic liver and kidney disease or Hematological Disorders • For 5-10 days
Patients with arrhythmia and chronic heart disease  
Patients known to have retinal disease or hearing loss  
Skin disorders (including rash, dermatitis, and psoriasis)  
Glucose-6-phosphate dehydrogenase (G6PD) deficiency  
Revise drug drug interaction carefully with pharmacist  
Piperacillin/Tazobactam 300 mg/ kg/day divided every 6-8 hours • For 5-10 days but may be extended on a case-bycase basis
Vancomycin 15 mg/kg/dose every 6 hours • For 5-10 days but may be extended on a case-bycase basis
Tocilizumab <30 kg: 12 mg/kg • H score with a value more than 169
  ≥30 kg: 8 mg/kg (max: 800 mg/dose) • Duration: One dose
   • Response usually seen at 48-72h
   • Don't exceed 800 mg/dose
Methylprednisolone 2 mg/kg/day • For 3-5 days when Tocilizumab not available