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Table 3 Relation between IL-1β (+ 3954 C>T), IL-6 (− 597 G>A), and IL-6 (− 174 G>C) and different clinical complications in sickle cell patients

From: Interleukin-1β and interleukin-6 gene polymorphisms in Egyptian sickle cell disease patients

 

Avascular necrosis, N = 8

Pulmonary hypertension, N = 24

Cholelithiasis,N = 17

Splenomegaly, N = 39

IL1ß (+ 3954C>T)

    

 Wild (CC)

3 (37%)

8 (33%)

7 (41%)

16 (41%)

 Mutant (CT, TT)

5 (63%)

16 (66%)

10 (59%)

23 (59%)

P value

0.656

0.187

0.728

0.523

IL6 (− 174 G>C)

    

 Wild (GG)

5 /7(71%)

17/21 (81%)

13/16 (81%)

25/32 (78%)

 Mutant (GC, CC)

2/7(29%)

4/21 (19%)

3/16 (19%)

7/32 (22%)

P value

0.819

0.463

0.518

0.501

IL-6 (− 597G>A)

    

 Wild (GG)

4 (50%)

20 (83%)

12 (71%)

28 (72%)

 Mutant (GA, AA)

4 (50%)

4 (17%)

5 (29%)

11 (28%)

P value

0.226

0.081

0.876

0.628