From: Interleukin-1β and interleukin-6 gene polymorphisms in Egyptian sickle cell disease patients
Avascular necrosis, N = 8 | Pulmonary hypertension, N = 24 | Cholelithiasis,N = 17 | Splenomegaly, N = 39 | |
---|---|---|---|---|
IL1ß (+ 3954C>T) | ||||
Wild (CC) | 3 (37%) | 8 (33%) | 7 (41%) | 16 (41%) |
Mutant (CT, TT) | 5 (63%) | 16 (66%) | 10 (59%) | 23 (59%) |
P value | 0.656 | 0.187 | 0.728 | 0.523 |
IL6 (− 174 G>C) | ||||
Wild (GG) | 5 /7(71%) | 17/21 (81%) | 13/16 (81%) | 25/32 (78%) |
Mutant (GC, CC) | 2/7(29%) | 4/21 (19%) | 3/16 (19%) | 7/32 (22%) |
P value | 0.819 | 0.463 | 0.518 | 0.501 |
IL-6 (− 597G>A) | ||||
Wild (GG) | 4 (50%) | 20 (83%) | 12 (71%) | 28 (72%) |
Mutant (GA, AA) | 4 (50%) | 4 (17%) | 5 (29%) | 11 (28%) |
P value | 0.226 | 0.081 | 0.876 | 0.628 |