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Table 3 Relation between IL-1β (+ 3954 C>T), IL-6 (− 597 G>A), and IL-6 (− 174 G>C) and different clinical complications in sickle cell patients

From: Interleukin-1β and interleukin-6 gene polymorphisms in Egyptian sickle cell disease patients

 Avascular necrosis, N = 8Pulmonary hypertension, N = 24Cholelithiasis,N = 17Splenomegaly, N = 39
IL1ß (+ 3954C>T)    
 Wild (CC)3 (37%)8 (33%)7 (41%)16 (41%)
 Mutant (CT, TT)5 (63%)16 (66%)10 (59%)23 (59%)
P value0.6560.1870.7280.523
IL6 (− 174 G>C)    
 Wild (GG)5 /7(71%)17/21 (81%)13/16 (81%)25/32 (78%)
 Mutant (GC, CC)2/7(29%)4/21 (19%)3/16 (19%)7/32 (22%)
P value0.8190.4630.5180.501
IL-6 (− 597G>A)    
 Wild (GG)4 (50%)20 (83%)12 (71%)28 (72%)
 Mutant (GA, AA)4 (50%)4 (17%)5 (29%)11 (28%)
P value0.2260.0810.8760.628