Table 2 IL-1β (+ 3954 C>T), IL-6 (− 174 G>C), and IL-6 (− 597G>A) polymorphisms; genotype and allele frequencies in SCD patients and in the control group
From: Interleukin-1β and interleukin-6 gene polymorphisms in Egyptian sickle cell disease patients
Polymorphism | Control, N (%) | SCD patients, N (%) | Odds ratios (95% CI) | P valuea |
|---|---|---|---|---|
IL-1β (+ 3954 C>T) | ||||
Wild genotype (CC) | 22 (44.0) | 45 (45.0) | 1.041 (0.526–2.062) | 0.908 |
Mutant genotype (CT + TT) | 28 (56.0) | 55 (55.0) | ||
C Allele | 70 (70.0) | 140 (70.0) | 1.000 (0.592–1.688) | 1.000 |
T Allele | 30 (30.0) | 60 (30.0) | ||
IL-6 (− 174G>C) | ||||
Wild (GG) | 37 (75.5) | 60 (75.0) | 1.027 (0.450–2.344) | 0.948 |
Mutant (GC + CC) | 12 (24.5) | 20 (25.0) | ||
G Allele | 85 (86.7) | 137 (85.6) | 0.911 (0.438–1.894) | 0.803 |
C Allele | 13 (13.3) | 23 (14.4) | ||
IL-6 (− 597G>A) | ||||
Wild (GG) | 40 (80.0) | 69 (69.0) | 0.556 (0.247–1.254) | 0.157 |
Mutant (GA + AA) | 10 (20.0) | 31 (31.0) | ||
G allele | 89 (89.0) | 165 (82.5) | 0.583 (0.282–1.203) | 0.144 |
A allele | 11 (11.0) | 35 (17.5) | ||