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Table 2 IL-1β (+ 3954 C>T), IL-6 (− 174 G>C), and IL-6 (− 597G>A) polymorphisms; genotype and allele frequencies in SCD patients and in the control group

From: Interleukin-1β and interleukin-6 gene polymorphisms in Egyptian sickle cell disease patients

PolymorphismControl, N (%)SCD patients, N (%)Odds ratios (95% CI)P valuea
IL-1β (+ 3954 C>T)
 Wild genotype (CC)22 (44.0)45 (45.0)1.041 (0.526–2.062)0.908
 Mutant genotype (CT + TT)28 (56.0)55 (55.0)
 C Allele70 (70.0)140 (70.0)1.000 (0.592–1.688)1.000
 T Allele30 (30.0)60 (30.0)
IL-6 (− 174G>C)
 Wild (GG)37 (75.5)60 (75.0)1.027 (0.450–2.344)0.948
 Mutant (GC + CC)12 (24.5)20 (25.0)
 G Allele85 (86.7)137 (85.6)0.911 (0.438–1.894)0.803
 C Allele13 (13.3)23 (14.4)
IL-6 (− 597G>A)
 Wild (GG)40 (80.0)69 (69.0)0.556 (0.247–1.254)0.157
 Mutant (GA + AA)10 (20.0)31 (31.0)
 G allele89 (89.0)165 (82.5)0.583 (0.282–1.203)0.144
 A allele11 (11.0)35 (17.5)
  1. aP < 0.05 is significant