Cognitive functions and anti-oxidant in children with sickle cell disease: A single center based study

Egyptian Pediatric Association Gazette

Table 4 Studied clinical and laboratory variables of SCD patients

Variable		Group I (n = 19)	Group II (n = 36	P value
Age in years (Mean ± SD)		8.76 ± 2.40	11.57 ± 3.36	0.002^*
Sex n (%)	Male	11 (57.9%)	9 (25%)	0.021^*
Sex n (%)	Female	8 (42.1%)	27 (75%)	0.021^*
Genotype n (%)	SS	12 (63.1%)	26 (72.2%)	0.548
Genotype n (%)	Sβ	7 (36.9%)	10 (27.8%)	0.548
SCD onset (Mean ± SD)		2.71 ± 2.75	3.87 ± 3.10	0.087
Severity score (Mean ± SD)		5.31 ± 2.08	4.72 ± 2.53	0.386
Hb (mg/dL) (Mean ± SD)		8.11 ± 1.61	7.78 ± 0.99	0.352
AST (U/L) (Mean ± SD)		38.26 ± 13.53	48.14 ± 20.26	0.036^*
ALT (U/L) (Mean ± SD)		23.4 ± 22.7	28.3 ± 17.5	0.540
TSB (mg/dL) (Mean ± SD)		1.27 ± 0.65	2.82 ± 3.37	<0.001^*
DSB (mg/dL) (Mean ± SD)		0.24 ± 0.11	0.44 ± 0.35	0.001^*
LDH (U/L) (Mean ± SD)		737.47 ± 462.88	641.15 ± 429.12	0.447
Ferritin (ng/mL) (Mean ± SD)		1037.19 ± 1081.68	625.83 ± 751.28	0.089
Hydroxyurea dose (mg/kg/d) (Mean ± SD)		17.36 ± 10.55	13.35 ± 7.85	0.087
Hydroxyurea duration of therapy in years (Mean ± SD)		1.76 ± 1.84	2.63 ± 3.06	0.152
Age at first blood transfusion (Mean ± SD)		1.46 ± 1.01	2.53 ± 2.14	0.174
Frequency of transfusion per year (Mean ± SD)		2.68 ± 2.71	2.03 ± 2.93	0.174
Vitamin E (μg/mL) (Mean ± SD)		3.07 ± 0.66	3.14 ± 0.65	0.736
Selenium (ng/mL) (Mean ± SD)		27.87 ± 18.18	27.85 ± 18.70	0.844

*Statistically significant, n = number, SD = standard deviation SS = homozygous hemoglobin, Sβ = heterozygous sickle beta thalassemia, Hb = Hemoglobin, AST = Aspartate aminotransferase, ALT = Alanine aminotransferase, TSB = total serum bilirubin, DSB = direct serum bilirubin, LDH = Lactate dehydrogenase