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Table 4 Studied clinical and laboratory variables of SCD patients

From: Cognitive functions and anti-oxidant in children with sickle cell disease: A single center based study

Variable Group I (n = 19) Group II (n = 36 P value
Age in years (Mean ± SD) 8.76 ± 2.40 11.57 ± 3.36 0.002*
Sex n (%) Male 11 (57.9%) 9 (25%) 0.021*
Female 8 (42.1%) 27 (75%)
Genotype n (%) SS 12 (63.1%) 26 (72.2%) 0.548
7 (36.9%) 10 (27.8%)
SCD onset (Mean ± SD) 2.71 ± 2.75 3.87 ± 3.10 0.087
Severity score (Mean ± SD) 5.31 ± 2.08 4.72 ± 2.53 0.386
Hb (mg/dL) (Mean ± SD) 8.11 ± 1.61 7.78 ± 0.99 0.352
AST (U/L) (Mean ± SD) 38.26 ± 13.53 48.14 ± 20.26 0.036*
ALT (U/L) (Mean ± SD) 23.4 ± 22.7 28.3 ± 17.5 0.540
TSB (mg/dL) (Mean ± SD) 1.27 ± 0.65 2.82 ± 3.37 <0.001*
DSB (mg/dL) (Mean ± SD) 0.24 ± 0.11 0.44 ± 0.35 0.001*
LDH (U/L) (Mean ± SD) 737.47 ± 462.88 641.15 ± 429.12 0.447
Ferritin (ng/mL) (Mean ± SD) 1037.19 ± 1081.68 625.83 ± 751.28 0.089
Hydroxyurea dose (mg/kg/d) (Mean ± SD) 17.36 ± 10.55 13.35 ± 7.85 0.087
Hydroxyurea duration of therapy in years (Mean ± SD) 1.76 ± 1.84 2.63 ± 3.06 0.152
Age at first blood transfusion (Mean ± SD) 1.46 ± 1.01 2.53 ± 2.14 0.174
Frequency of transfusion per year (Mean ± SD) 2.68 ± 2.71 2.03 ± 2.93 0.174
Vitamin E (μg/mL) (Mean ± SD) 3.07 ± 0.66 3.14 ± 0.65 0.736
Selenium (ng/mL) (Mean ± SD) 27.87 ± 18.18 27.85 ± 18.70 0.844
  1. *Statistically significant, n = number, SD = standard deviation SS = homozygous hemoglobin, Sβ = heterozygous sickle beta thalassemia, Hb = Hemoglobin, AST = Aspartate aminotransferase, ALT = Alanine aminotransferase, TSB = total serum bilirubin, DSB = direct serum bilirubin, LDH = Lactate dehydrogenase