Effectiveness of two concentrations 12% versus 38% of silver diamine fluoride in arresting cavitated dentin caries among children: a systematic review

Egyptian Pediatric Association Gazette

Table 1 Summary of the studies selected for this systematic review

Study ID	Subjects age (years) Range, mean (SD)	Teeth	Total no. of patients/drop out	Grouping	Trial length/months	Outcome
Yee et al. [16]	3–9, 5.2 (1.2)	Primary teeth	976 children At 6 months, 908 At 12 months, 768 At 24 months, 634	Group 1: One application of 38% SDF for 2 min without a reducing agent Group 2: One application of 38% SDF for 2 min with tea as a reducing agent Group 3: One application of 12% SDF for 2 min without a reducing agent Group 4: No treatment for carious teeth This was the control group.	24	Mean number of active cavitated surfaces at baseline that changed at 6, 12, and 24 months’ follow-up examination into surfaces with arrested cavitated caries
Fung et al. [17, 18]*	3–4, 3.8 (0.6)	Primary teeth	888 children At 6 months, 888 At 12 months, 850 At 18 months, 831 at 24 months, 806 at 30 months, 799	Group 1: 12% SDF applied every 12 months Group 2: 12% SDF applied every 6 months Group 3: 38% SDF applied every 12 months Group 4: 38% SDF applied every 6 months	18 (2016) 30 (2018)	Tooth surface-level caries arrest rates at 6, 12, 18, 24, and 30 months’ examinations n/N (%). Mean (SD) numbers of tooth surfaces with arrested caries at 30 months follow-up.

*Fung et al.: Two publication reports with different follow-up [first 2016 (6, 12, and 18 months follow-up); second 2018 (24 and 30 months follow-up)]